Amaphilisi angenalutho angelinye lamafomu emithamo ajwayelekile embonini yezemithi nesengezo sezempilo ngenxa yokunambitheka kwawo okuhle-izici zokufihla, ukutholakala okuphezulu kwe-bioavailability, nokuphatheka. Kodwa-ke, phakathi{2}}nenqubo yokugcwalisa okuzenzakalelayo ephezulu{2}}, amaphilisi angenalutho angaqhuma, awonakale, noma aphathwe kabi ngenxa yamapharamitha wemishini, izici ezibonakalayo, nezici zemvelo. Lokhu akuholeli nje kuphela ekuvuzeni kwempushana kanye nokwanda kwemvamisa yokuphelelwa yisikhathi kwemishini ukuze kuhlanzwe kodwa kuphinde kube nomthelela omkhulu ekukhiqizweni komkhiqizo. Ukuze uvimbele ama-capsules angenalutho ekuqhekekeni ngesikhathi sokugcwalisa, kuyadingeka ukugxila ezindaweni ezintathu ezibalulekile: ukulawulwa kwezinto ezibonakalayo, ukulungiswa kwemishini, nokuphathwa kwemvelo.
Okokuqala, ukulawula ngokuqinile ibhalansi yomswakama phakathi kwezinto zokugcwalisa nama-capsules kubalulekile. Ingxenye eyinhloko yama-capsules angenalutho i-gelatin futhi inezinto zombili ze-hygroscopic kanye ne-dewatering. Uma i-powder noma ama-granules agcwaliswayo anomswakama ophansi kakhulu (owome ngokweqile), umswakama wegobolondo le-capsule uzomuncwa ngokushesha into, okubangela ukuthi igobolondo libe brittle futhi lithambekele kakhulu ekuqhekekeni ngesikhathi sokukhiya komshini. Ngokuphambene, uma impahla noma umswakama wemvelo uphezulu kakhulu, i-capsule iba manzi futhi ithambe, okuholela ekuguquguqukeni noma ekuvinjweni. Ngakho-ke, kubalulekile ukulawula ngokuqinile isilinganiso somswakama wezinto ezibonakalayo nama-capsules. Ngokuvamile kunconywa ukugcina ibhalansi yomswakama efanayo phakathi kokubili; uma kunesidingo, ukwelashwa okufanele kwe-spray humidification kungasetshenziswa kuma-capsules.
Okwesibili, ukwenza ngcono amapharamitha wemishini kanye nokuqinisekisa ukuhambisana kwesikhunta kubaluleke kakhulu. Ukusebenza-okushesha kakhulu kwemishini yokugcwalisa ama-capsule kunikeza ingcindezi enkulu kumakhepsuli. Uma kukhona ukungafani phakathi kosayizi/ukucaciswa kwezimbobo zesikhunta kanye nemodeli ye-capsule, noma uma okokusebenza kusebenza ngesivinini eseqile, amaphilisi angase abe ngaphansi kwamandla okucindezela ngesikhathi sokuthutha, ukuhlukaniswa, noma ukuvalwa, okuholela ekuqhekekeni. Ukwengeza, kubalulekile ukuhlola njalo futhi ulinganise amandla okukhiya (ingcindezi yokukhiya) yomshini wokugcwalisa. Amandla okukhiya amaningi angayichoboza i-capsule, kuyilapho amandla anganele angabangela ukukhiya okuxegayo noma ukwehliswa kwekepisi{5}}. Ama-opharetha kufanele alungise{7}}i-vacuum yesisetshenziswa kanye ne-mechanical plunger pressure ngokusekelwe ezicini zamaqoqo ama-capsule ahlukene ukuze kuqinisekiswe Ukufika Okuthambile kanye Nokukhiya Okumnene.
Okokugcina, ukugcina indawo efanelekile yokukhiqiza enezinga lokushisa elilawulwayo kanye nomswakama kusebenza njengesivikelo. Amaphilisi angenalutho azwela kakhulu endaweni yawo; amazinga okushisa aphansi angenza i-gelatin ibe brittle, kuyilapho umswakama ophezulu ungayenza ithambe. Ngokuvamile kunconywa ukuthi izinga lokushisa endaweni yokusebenzela yokukhiqiza lilawulwe phakathi kwama-20-25 degrees, nomswakama ohambisanayo ogcinwe phakathi kuka-45% -60%. Indawo ezinzile enokushisa okungapheli kanye nomswakama inganciphisa ukuguquguquka kwezinto ezibonakalayo zamaphilisi, ngaleyo ndlela kunciphise ingozi yokuphuka.
Kafushane, ukuvimbelaamaphilisi angenaluthokusukela ekuqhekekeni ngesikhathi sokugcwalisa kudinga abakhiqizi ukuthi basungule inqubo yokusebenza esezingeni elihlanganisa{0}}ukwelashwa kwangaphambili kwezinto, ukuphathwa kwezinto ezicolisisiwe, nokulawulwa kwemvelo. Kuphela ngokunaka imininingwane nokuphatha ngokwesayensi izinga lokuqhekeka lingancishiswa ngempumelelo, kuqinisekiswe kokubili ukusebenza kahle kokukhiqiza kanye nekhwalithi ephezulu yomkhiqizo. Uma kukhona imibuzo mayelana namaphilisi angenalutho, Siyakwamukela ukuthintana ne-KornnacCaps.
