Amaphilisi angenalutho asebenza njengabathwali ababalulekile bemithi nemithi, futhi izakhiwo zabo ezingokomzimba zizwela kakhulu. Phakathi kwalokhu, okuqukethwe komswakama kuyinkomba yekhwalithi ewujuqu. Umswakama owedlulele ungabangela amaphilisi ukuthi athambe, akhubazeke, noma anamathele ndawonye, kuyilapho umswakama onganele uwenza abe brittle futhi athambekele ekuqhekekeni ngesikhathi sokuthutha nokugcinwa. Ngakho-ke, ukuthola umswakama wamaphilisi angenalutho ngokwesayensi nangokunembile kuyingxenye ebalulekile yokulawulwa kwekhwalithi ezinkampanini ezithaka imithi.
Njengamanje, ukutholwa kokuqukethwe komswakama kuma-capsules angenalutho kuncike ngokuyinhloko kumgomo wokushintsha isisindo somzimba kanye nokuhlaziywa kwamakhemikhali. Ekuhlolweni okujwayelekile okunqunywe yi-pharmacopeias, indlela evame ukusetshenziswa kakhulu yindlela yokulahleka kokoma (LOD). Lokhu kuhilela ukushisisa isampula ukuze amanzi ahwamuke, bese kubalwa umswakama osuselwe kumehluko wesisindo ngaphambi nangemuva kokumiswa. Kumaphilisi e-gelatin, ukulawula izinga lokushisa okuqinile ngesikhathi sokuhlolwa kubalulekile ngenxa yokuzwela kwawo okushisayo; i-oven eyomisa izinga lokushisa engashintshi ngokuvamile isetshenziswa. Ukuze uvimbele ukukhishwa okushisayo kwe-gelatin, ukomiswa kwe-vacuum ngezinye izikhathi kusetshenziswa, okuvumela umswakama ukuba uhwamuke emazingeni okushisa aphansi ngaphansi kwengcindezi encishisiwe. Nakuba le ndlela yakudala iveza imiphumela enembile, ngokuvamile idla isikhathi-futhi kunzima ukuhlangabezana nesidingo sempendulo esheshayo emigqeni yokukhiqiza yesimanje.
Ukuthuthukisa ukusebenza kahle kokuhlola, abahlaziyi bomswakama abasheshayo bathole ukusetshenziswa okusabalele embonini eminyakeni yamuva nje. Lawa mathuluzi ngokuvamile asebenzisa ukushisisa kwe-halogen noma ubuchwepheshe bemisebe ye-infrared ukushisa amasampuli ngokuqondile, okufinyeza kakhulu isikhathi sokumisa. Isimiso sabo sokusebenza sisekelwe nasekuncipheni kwesisindo, kodwa bahlanganisa{2}}izinzwa ezinesisindo esinembayo kanye namasistimu okulawula izinga lokushisa ahlakaniphile ukuze kuqashwe ngokuzenzakalelayo izinguquko esisindweni sesampula nokubala okuqukethwe komswakama ngesikhathi sangempela. Uma kuqhathaniswa nezindlela zikahhavini ezivamile, le ndlela iqeda isidingo sokukala nokupholisa okwenziwa ngokuphindaphindiwe, ihlinzeka ngemiphumela phakathi namaminithi, iyenze ifaneleke{4}}ekulawulweni kwenqubo kanye nokuhlola ngokushesha phakathi nokukhiqiza.
Ngaphandle kwezindlela ezisekelwe ezimisweni ze-thermogravimetric, i-Karl Fischer titration ingenye indlela ebalulekile yokuthola. Le ndlela yamakhemikhali inquma okuqukethwe komswakamo ngokusekelwe ekuphenduleni kwamakhemikhali obuningi phakathi kwe-iodine namanzi. Kumakhepsuli angenalutho ashisa kakhulu-azwelayo noma aqukethe izingxenye eziguquguqukayo, i-Karl Fischer titration inikeza ukunemba okuphezulu kakhulu kokutholwa futhi inganquma ngisho namanani omkhondo womswakamo. Kodwa-ke, ngenxa yezidingo zayo eziphezulu zama-reagents nendawo ezungezile, kanye nobunkimbinkimbi bayo obuhlobene, ngokuvamile isetshenziselwa ukuhlaziya umbango noma izinkambu zocwaningo kunokuba kube yinketho eyinhloko yokukhiqiza kwansuku zonke.
Ngaphezu kwalokho, ngokuthuthukiswa kokukhiqiza okuhlakaniphile embonini yezemithi, i-Near-I-Infrared Spectroscopy (NIR) nayo isiqalile ukusetshenziswa ekutholweni kwe-inthanethi komswakama we-capsule. Le nqubo -engonakali yokuhlola ibikezela okuqukethwe komswakama ngokuhlaziya isici sokumuncwa samasampula ebangeni eliseduze-lokukhanya kwe-infrared kuhlanganiswe namamodeli ezibalo. Izinzuzo zayo ezinkulu zibandakanya ukungabi bikho kwesampula yokucekela phansi, akukho ama-reagents, kanye nezivinini zokutholwa ezishesha kakhulu, ukunika amandla-isikhathi sangempela, ukuqapha okuqhubekayo nokumelela isiqondiso esibalulekile sokwakhiwa kwezimboni ezihlakaniphile esikhathini esizayo.
Kafushane, kunezindlela ezahlukahlukene zokuthola umswakama weamaphilisi angenalutho. Ezinhlelweni ezisebenzayo, amabhizinisi kufanele akhethe indlela yokuhlonza efanele ngokusekelwe ezidingweni zawo zenqubo ethile, ukunemba kokutholwa okudingekayo, kanye nesivinini sokukhiqiza. Ukuthi kusetshenziswa indlela ye-ovini yendabuko noma abahlaziyi abasheshayo besimanje, ukuqinisekisa ukunemba nokuzinza kwedatha yokuthola kuhloswe ekugcineni ukuqinisekisa ikhwalithi yamaphilisi angenalutho, ngaleyo ndlela kuqinisekiswe ukuphepha nokusebenza ngempumelelo kwemikhiqizo yezokwelapha. Uma kukhona izimfuno kumaphilisi angenalutho, Siyakwamukela ukuthintana ne-KornnacCaps.
