Ngokudlondlobala kokuduma komqondo "wezempilo yemvelo", amaphilisi emifino (njengamakhepsuli e-HPMC namakhepsuli e-Pullulan) kancane kancane athatha indawo yamakhepsuli e-gelatin endabuko ngenxa yesitshalo{{0}semvelaphi yawo,{1}}ukwakheka kwamahhala kwezilwane, umswakama ophansi, kanye nokuvumelana nezimo zenkolo okubanzi. Kodwa-ke, izakhiwo ze-physicochemical of capsules zemifino zihluke kakhulu ku-gelatin, futhi ngokuvamile zizwela kakhulu ezintweni zemvelo. Indlela yokuqinisekisa ukuzinza kwama-capsules emifino ngesikhathi sokugcinwa nokuthutha sekugxilwe kakhulu ezimbonini zezemithi nezezempilo. Okulandelayo amasu amaningana abalulekile okuqinisekisa ukuzinza kweama-capsules wemifino.
1. Lawula Ngokuqinile Indawo Yokukhiqiza Nokuqukethwe Komswakama Ophansi
Amaphilisi emifino ngokuvamile anomswakama ophansi kakhulu (imvamisa phakathi kuka-4% no-6%). Nakuba lokhu kunciphisa ngempumelelo ingcuphe yokukhula kwamagciwane, kuphinde kubenze bazwele kakhulu kumswakama wendawo. Ukuqinisekisa ukuzinza, inqubo yokukhiqiza kufanele yenziwe ngaphansi kwezimo eziqinile zokushisa kanye nomswakama. Ngesikhathi esifanayo, ngenxa yokuthi ukwakheka kwe-molecular of capsules yemifino ayiminyene njengaleyo ye-gelatin, amandla awo okukhiya{5}}abuthakathaka. Ngakho-ke, kuyadingeka ukulungisa ukungena komoya kanye nomswakama wegobolondo le-capsule ngokusebenzisa izinqubo ezikhethekile zokubumba ukuvimbela ukonakala ezindaweni ezomile noma ukuthambisa ezindaweni ezinomswakama.
2. Ukufakwa Kwezithako Ezisebenzayo kanye Nokuguqulwa Kwefomula
Izinto ezihlanzekile zezitshalo zemvelo ngokuvamile zihlushwa amandla anganele emishini noma ukuqina okuphezulu. Ukuze kuthuthukiswe ukuzinza kwama-capsules emifino, abakhiqizi bengeza ama-gelling agents (njenge-carrageenan) nama-plasticizers (njenge-glycerin) kufomula. Lezi zengezo zingalawula ngempumelelo ukuguquguquka nokunwebeka kwegobolondo le-capsule, ukuvimbela ama-capsules ukuthi angaqhekeki noma aqhekeke ngenxa yokudlidliza ngesikhathi sokuthutha, ngaleyo ndlela agcine ubuqotho besimo sawo somzimba.
3. Ukuthuthukiswa Kokuhambisana Kwezinto Zokugcwalisa
Ukuhambisana phakathi kwegobolondo le-capsule nezinto zokugcwalisa (okuqukethwe) kuyisici esiyinhloko esithinta ukuzinza. Amaphilisi emifino ngokuvamile ane-alkaline ebuthakathaka. Uma okuqukethwe kuqukethe i-aldehydes noma kune-hygroscopicity eqinile, kungaholela kalula-ekuhlanganiseni kokusabela okuxhumanisayo noma ukonakala kwekhepisi. Ngakho-ke, ukuhlolwa kokuhambisana okuqinile kuyadingeka ngaphambi kokugcwalisa. Uma kudingekile, okokusebenza kokugcwalisa kufanele kufakwe ngaphansi-ku-encapsulation noma kubhanqwe nama-desiccant angaphakathi ukuze kuhlukaniswe ukudluliswa komswakama futhi kuqinisekiswe-ukuhambisana kwesikhathi eside phakathi kwegobolondo le-capsule nomuthi wangaphakathi.
4. Ukupakishwa Kwesayensi Nokuphathwa Kwesitoreji
Ukupakisha kusebenza njengomugqa wokugcina wokuvikela ukuzinza kwamaphilisi emifino. Ukusebenzisa amaphakethe e-aluminium blister (PTP/PVC) noma{1}}amabhodlela epulasitiki avimbelayo aphezulu, ahlanganiswe nama-desiccant akhelwe ngaphakathi, kungavimba ngempumelelo ukungena komoyampilo wangaphandle kanye nomswakama. Mayelana nesitoreji, kunconywa ukuthi ulawule izinga lokushisa eliphakathi kuka-15 no-25 degrees futhi ugcine umswakama ophakathi kuka-35% no-65%. Ukugwema ukushintshashintsha kwezinga lokushisa nomswakama okwedlulele kusiza ukuvimbela ukuguga kwe-capsule noma ukwehluleka ukuhlangabezana nemikhawulo yesikhathi sokuhlakazeka.
Kafushane, ukuqinisekisa ukuzinza kwamaphilisi emifino kudinga indlela ebanzi ehlanganisa ukwakheka kwefomula, izinqubo zokukhiqiza, ukuhambisana kokugcwalisa, kanye nesitoreji sokupakisha. Ngokuphathwa kwekhwalithi eqinile kuphela lapho izinzuzo zamaphilisi emifino-ukuba "emvelo, ephephile, futhi ezinzile"{2}}zingakhuliswa, kunikeze isiqinisekiso esiqinile semikhiqizo yokugcina. Uma kukhona imibuzo mayelana namaphilisi angenalutho, wamukelekile ukuthintana ne-KornnacCaps.
