Wake wazibuza ukuthi kungani behlakaniphe kangaka uma uthola amaphilisi ebhokisini lakho lemithi adinga ukuwaphuza ungadlanga lutho akubangeli ukungakhululeki kwesisu? Impendulo ilele kugobolondo lazo elingaphandle, i-enteric{0}}capsule ehlanganisiwe. Ngakho, ziyini ngempelai-enteric-kunandiweamaphilisiyenziwe ngani? Namuhla, ake siphakamise iveli emfihlakalo yayo.
Izingxenye Eziyinhloko: Ukuguqulwa KweGelatin noma Ijeli Yezitshalo
Izinto eziyisisekelo zama-enteric{0}}ama-capsules ahlanganiswe ngokuvamile i-gelatin. I-Gelatin iyiphrotheni ekhishwa emathanjeni esilwane noma esikhunjeni, eyaziwa ngefilimu yayo enhle{2}}ukwakheka kwezakhiwo kanye nokuvumelana kwe-biocompatibility, okuyenza kube ukukhetha ngokwesiko ukwenza amagobolondo ama-capsule ajwayelekile. Ukuze uhlangabezane nezidingo ezikhethekile zemithi ethile yepheshana lamathumbu, lezi zinto eziyisisekelo zidinga ukucubungula okwesibili.
Isici Esibalulekile: I-Enteric Coated Layer
Isizathu sokuthi kungani ama-capsules{0}}ahlanganisiwe ahlala eqinile-esiswini futhi ehlephuka ngokushesha emathunjini ilele ekhethekile evalwe nge-enteric ebusweni begobolondo le-capsule. Le nto yokumboza iyisihluthulelo sokunquma ukusebenza kwayo. Izinto ezivamile{4}ezinamekiwe zama-enteric ziwela kakhulu ezigabeni ezimbili:
Okuphuma ku-Cellulose: Okufana ne-cellulose acetate phthalate (CAP), i-hydroxypropyl methylcellulose phthalate(HPMCP), njll. Lezi zinto ziqinile futhi azincibiliki endaweni ene-asidi yejusi yesisu, ngaleyo ndlela ivikela umuthi wangaphakathi. Lapho i-capsule ifinyelela endaweni yamathumbu enenani eliphakeme le-pH, lezi zinto ziyancibilika, okubangele ukuthi igobolondo le-capsule livuleke futhi likhulule umuthi.
Ama-Acrylic Resins: Lawa ma-resin abuye abe nesici sokuzinza endaweni ene-acidic futhi ancibilike endaweni ene-alkali, awenze abe enye into esetshenziswa kakhulu yama-enteric.
Izidingo Ezikhethekile: Izitshalo-Ezihlukile Ezisekelwe kwezinye
Uma kucatshangelwa izidingo zamaqembu athile abantu (njengabadla imifino noma labo abangazwani nemikhiqizo yezilwane), akhona futhi{0}}amakhepsuli anama-enteric emakethe enziwe ngejeli yezitshalo (njenge-HPMC) njengesisekelo bese ephathwa nge-enteric coating. Lokhu kunikeza izinketho ezengeziwe ezigulini.
Isikhala Sangaphakathi: Indawo Ephephile Yomuthi
Ingxenye Engenalutho ye-enteric-capsule coated yakhelwe ukumumatha umuthi. Ingagcwaliswa ngezinhlobo ezahlukene zemithamo yezidakamizwa, kungakhathaliseki ukuthi ziyizimpushana, ama-granules, noma ama-pellets. Le acid-emelana negobolondo le-capsule isebenza njengendawo ephephile yesikhashana, iqinisekisa ukuthi umuthi uhlala uzinzile ngaphambi kokufika endaweni yawo (amathumbu), awubhujiswa i-asidi yesisu, futhi ugwema ukucasuka ku-mucosa yesisu.
Kafushane: Umnakekeli Wezempilo Oklanywe Ngokunembile
Ekuphetheni,i-enteric-capsule e-coatedyakhiwe ngezinto eziyisisekelo (i-gelatin noma ijeli yesitshalo) kanye nongqimba olubalulekile lwe-enteric (njenge-CAP, HPMCP, njll.). Lo mklamo onembile uyivumela ukuthi ilethe izidakamizwa emathunjini ngokunembile, idlala indima engenakushintshwa ekuvikeleni umsebenzi wezidakamizwa, ekwehliseni imiphumela emibi yesisu, kanye nokwenza ngcono ukusebenza kwezidakamizwa. Ngokuzayo uma uthatha i-enteric{3}}capsule enandiwe, mhlawumbe ungase ube nokuqonda okwengeziwe kanye nenhlonipho ngale Cloak encane Engabonakali. Uma ufuna ukufunda okwengeziwe mayelana-namakhepsuli ane-coated noma ama-excipients ekhemisi ahlobene, sicela ukhululeke ukuqhubeka usilandele.
