I-Enteric Engenalutho-Ama-Capsules Ahlanganisiweziwuhlobo olukhethekile lwefomu lomthamo wezidakamizwa. Amagobolondo awo enziwe ngezinto ezikhethekile, ezingahlala ziqinile ngaphansi kwesenzo se-asidi yesisu futhi zincibilike endaweni ene-alkali yamathumbu, ngaleyo ndlela kuzuzwe ukukhululwa kwezidakamizwa okunembile. Lo mklamo uletha izinzuzo ezibalulekile ekulethweni kwezidakamizwa futhi usetshenziswa kakhulu emkhakheni wezokwelapha.
1. Vikela Umuthi Ekulinyazweni I-Gastric Acid
Inzuzo ebaluleke kakhulu yama-enteric-amaphilisi angenalutho agqinsiwe isekundleni kwawo ukuvikela izidakamizwa ukuthi zingalinyazwa i-asidi yesisu. Izidakamizwa eziningi zingase zilahlekelwe umsebenzi wazo noma zibole ngaphansi kwesenzo se-gastric acid, ngaleyo ndlela zinciphise ukusebenza kwazo. Isibonelo, amanye ama-antibiotics, izidakamizwa zamaprotheni kanye nalezo ezidinga ukukhishwa endaweni ene-alkaline zingagwema umthelela we-asidi yesisu ngokwenza amaphilisi{3}}agcwele angenalutho, aqinisekise ukuthi imithi ihlala isebenza ngemva kokufika emgudwini wamathumbu.
2. Yehlisa Ukucasuka ku-Gastric Mucosa
Igobolondo lama-enteric{0}}amakhepsuli angenalutho aboshwe angahlala eqinile esiswini, ngaleyo ndlela ehlise ukucasuka okuqondile komuthi ku-mucosa yesisu. Lokhu kubaluleke kakhulu kwezinye izidakamizwa ezingase zidale ukungaphatheki kahle emathunjini. Ngokwesibonelo, izidakamizwa ezifana ne-aspirin, ngemva kokwenziwa zaba ama-enteric-amaphilisi angenalutho ane-enteric, zinganciphisa kakhulu ukucasuka kwesisu futhi zehlise ukuvela kokusabela okungekuhle emgudwini wamathumbu.
3. Ukuthuthukisa I-Bioavailability kanye nokusebenza Kwezidakamizwa
Amaphilisi angenalutho e-Enteric{0}ahlanganiswe angakwazi ukukhiqiza izidakamizwa ezihloselwe emathunjini futhi athuthukise i-bioavailability yezidakamizwa. Ngokukhipha izidakamizwa kumasayithi athile emathunjini, amaphilisi{2}}ahlanganiswe angenalutho angakhuphula indawo yokuxhumana phakathi kwezidakamizwa nodonga lwamathumbu, ngaleyo ndlela athuthukise ukumuncwa kwezidakamizwa. Le ndlela yokukhululwa kwezidakamizwa enembile ayigcini nje ngokuthuthukisa umphumela wokwelapha kodwa futhi inciphisa ukulahlekelwa kwezidakamizwa esiswini.
4. Yelula Isikhathi Sokusebenza Kwezidakamizwa
Igobolondo lekhepsuli lamakhepsuli angenalutho{0}avaliwe anezinga elithile lokunwebeka futhi lingasebenza njengesivimbeli ngemva kokulithatha, linciphise umonakalo womuthi ku-mucosa yamathumbu. Khonamanjalo, igobolondo le-capsule lingavimbela umuthi ukuthi ungancibiliki futhi ukhululwe ngokushesha, ngaleyo ndlela andise isikhathi sokusebenza somuthi futhi uthuthukise umphumela wokwelapha. Lesi sici sibaluleke kakhulu emithini edinga ukusebenza ngokuqhubekayo isikhathi eside.
5. Izimo Ezibanzi Zokusebenza
Amaphilisi angenalutho e-Enteric{0}avamise ukusetshenziswa njengamaphakeji akhethekile ezidakamizwa noma imikhiqizo yezempilo ecunula isisu noma engazinzi lapho kukhona i-asidi. Isibonelo, izidakamizwa ze-protein polypeptide, amalungiselelo ebhaktheriya aphilayo, njll. zingapakishwa kuma-capsules angenalutho{3}ezinamekiwe. Ngaphezu kwalokho, ama-capsules{5}ahlanganisiwe asetshenziswa kabanzi ekwelapheni izifo zamathumbu kanye{6}}ezingezona zamathumbu njengokuqunjelwa, ukuqunjelwa kanye nomdlavuza webala. Ngemisebenzi efana nokuvikela umuthi, ukukhishwa kwezidakamizwa okuhlosiwe kanye nokwelula isikhathi sokusebenza somuthi, amaphilisi{8}}ahlanganiswe nge-enteric angaqinisekisa ukuthi umuthi uzuza umphumela wokwelapha ongcono kakhulu kumzila wamathumbu, kuyilapho ehlisa ukusabela okubi nokucasuka.
6. Inqubekelaphambili Yezobuchwepheshe Neziqondiso Zokuthuthukiswa Kwekusasa
Eminyakeni yakamuva, ubuchwepheshe bama-enteric{0}}ama-capsules angenalutho agqinsiwe bebulokhu buthuthuka, futhi izinto ezintsha nobuchwepheshe obusha bebulokhu buvela. Isibonelo, ukusetshenziswa kwezinto ezintsha ze-enteric-ezinamekwe nge-polymer kuthuthukise ukuzinza nokukhonjwa kwamakhepsuli angenalutho{3}enziwe nge-enteric. Ngokuzayo, ubuchwepheshe be-enteric{5}}embozwe nge-capsule obuyimbobo buzothuthukela ekunakekelweni kwezokwelapha komuntu siqu kanye nobuhlakani. Ngokulawula ngokunembile izinga lokukhululwa komuthi nendawo, uzohlangabezana nezidingo zokwelashwa zeziguli ezithile. Ukwengeza, ukuthuthukiswa kwama-capsules ahlakaniphile{8}ahlanganiswe angenalutho e-enteric, uma ehlanganiswa-nezinzwa ezincane ukuze kuqashwe indawo yamathumbu kanye nesimo sokukhishwa kwezidakamizwa, kuzoletha izinguquko ezinguqukweni ekulawulweni kwezifo kanye nocwaningo lomtholampilo.
Isifinyezo
Ama-capsules angenalutho e-Enteric{0}enamekiwezidlala indima ebalulekile emkhakheni wezokwelapha ngezinzuzo zazo eziningi njengokuvikela izidakamizwa, ukunciphisa ukucasuka nokuthuthukisa imiphumela yokwelapha. Ngokuthuthuka okuqhubekayo kobuchwepheshe, amathuba okusetshenziswa kwamaphilisi angenalutho{1}ahlanganiswe nama-enteric azoba banzi, anikeze iziguli izinketho zokwelashwa eziphephile nezisebenza ngempumelelo. Uma kukhona okufunwayo kumaphilisi angenalutho, wamukelekile ukuthintana ne-KornnacCaps.
