Njengesithwali esibalulekile samalungiselelo emithi, ukuzinza kwamaphilisi e-gelatin kuthinta ngqo ikhwalithi nokuphepha kwezidakamizwa. Phakathi kwezici ezihlukahlukene ezithinta ukuzinza, i-thermal denaturation iyisici esibucayi esidinga ukunakwa okuseduze ngesikhathi sokugcinwa, ukuthutha, nokusetshenziswa kwalawa ma-capsules, njengoba kuthonya ngokuqondile ubuqotho babo besakhiwo kanye nokusebenza kokukhululwa kwezidakamizwa.
I-Gelatin iyiphrotheni yemvelo ephezulu-yesisindo-ephezulu amaketanga wamamolekyuli agcina ukwakheka okuthathu-kwe-helix ngokusebenzisana njengamabhondi e-hydrogen. Uma izinga lokushisa le-ambient lidlula inani lalo elibalulekile, lawa maketanga e-gelatin yamangqamuzana ashintshashintsha ukusuka esakhiweni se-helical esihlelekile siye esakhiweni sekhoyili esingahleliwe esingahlelekile. Le nqubo yaziwa ngokuthi i-thermal denaturation. Izinga lokushisa elishisayo lamakhepsuli e-gelatin ngokuvamile liphakathi kuka-35℃kanye nama-degree angu-40 , ngevelu ethile ethonywa izici ezifana nomthombo we-gelatin (isb., isikhumba sengulube, isikhumba senkomo, noma ithambo lezinhlanzi), amandla okuqhakaza, okuqukethwe komswakama, nezinhlobo zezithasiselo ezisetshenziswayo. Ngokwesibonelo,{11}i-gelatin eqhakazayo ephezulu, enezinga eliphezulu lokuxhumanisa kwe-molecular chain cross{12}}ivame ukuba nezinga lokushisa eliphakeme le-denaturation, kanti umswakama owandayo ungenza buthaka amabhondi e-hydrogen, okuholela ekushiseni okuphansi kwe-denaturation.
Umthelela we-denaturation eshisayo ekusebenzeni kwe-capsule ubonakala ngokuyinhloko ezicini ezintathu. Okokuqala, kuholela ekwehleni kwezakhiwo zemishini; amagobolondo e-capsule ane-denatured ayathamba, alahlekelwe ukunwebeka, futhi athambekele ekunamatheleni, ekuwohlokeni, noma ekudabukeni. Okwesibili, kushintsha ukungeneka, njengoba ukuhlelwa kabusha kwamaketanga emolekyuli kungase kukhuphule usayizi wembotshana yodonga lwekhepsuli, kuthinte ukumelana nomswakama womuthi kanye nezakhiwo ezivimbela ukukhanya-. Okwesithathu, kungabangela ukusebenza okungavamile kokuhlakazeka, njengoba i-denaturation ingase iphazamise izakhiwo zokuvuvukala kwe-gelatin, okuholela ekukhululweni kwezidakamizwa okulibaziseka noma okungasebenzi. Isibonelo, ezindaweni zokushisa-eziphezulu kanye{6}}nomswakama ophezulu, ama-capsules angase abonise i-Softening and Adhesion phenomenon, okulimaza kakhulu ukupakishwa nokusetshenziswa kwawo.
Ukuze kuncishiswe izingozi ezihlobene nokushintshashintsha kwe-thermal, ukukhiqizwa kwama-capsules we-gelatin kudinga ukwakheka okulungiselelwe. Lokhu kungase kuhlanganise ukungeza ama-plasticizers afana ne-glycerin noma i-sorbitol ukuze kuthuthukiswe ukuguquguquka kwamaketanga e-molecular noma ukusebenzisa-ama-agent axhumanisayo ukuze kuthuthukiswe ukuqina kokushisa. Ngesikhathi sokulondoloza, ukulawula okuqinile kwezinga lokushisa nokuswakama kubalulekile (ngokuvamile kudinga izinga lokushisa elingaphansi kwamadigri angu-25 nomswakama ohlobene ongaphansi kuka-60%), ukugwema ukukhanya kwelanga kanye{5}}nezindawo zokushisa eziphezulu. Ngaphezu kwalokho, izinto ezintsha ze-capsule, ezifana (i-hydroxypropyl methylcellulose) amaphilisi e-HPMC, anezinga lokushisa eliphakeme kakhulu lokukhishwa kwe-thermal (angafinyelela ngaphezu kwamadigri angu-70), kancane kancane aphenduka ezinye izindlela ezikahle zokwakhiwa kwezidakamizwa ezihloselwe-izindawo zokushisa eziphezulu.
Sengiphetha, i-thermal denaturation iyisici esingokwemvelo seama-capsules we-gelatinokumele kulawulwe ngokuthuthukiswa kwezinto, ukulawulwa kwenqubo, nokugcinwa okujwayelekile. Ukuqonda kahle lesi sakhiwo kubalulekile ekuqinisekiseni ikhwalithi yomuthi, ukwelula impilo yeshalofu, futhi kuhlinzeke ngesisekelo sethiyori socwaningo nokuthuthukiswa kwezinto ezintsha zama-capsule. Uma kukhona okufunwayo kumaphilisi angenalutho, wamukelekile ukuthintana ne-KornnacCaps.
