Engadini yamalungiselelo emithi,ama-capsules{0}e-entericzifana nembali eyingqayizivele, ekhanya ngokukhazimulayo emkhakheni wezokwelapha ngomklamo wazo omuhle kanye nezici ezihlukile zokukhishwa kwezidakamizwa. Kufana noSokhemisi onekhono eliphezulu, eletha umuthi ngokuqondile endaweni ethintekile, ekhulisa ukusebenza kahle komuthi, futhi ngesikhathi esifanayo evikela izingxenye zezidakamizwa ezintekenteke ekugugulekeni kwe-asidi yesisu. Lesi sihloko sizocubungula izinkambu zokusetshenziswa kwama-capsules{2}}enziwe nge-coated futhi siphakamise iveli lemfihlakalo elizungeze ukusetshenziswa kwawo okubanzi embonini yezemithi.
1. Iyini i-Enteric-Coated Capsule?
Ama-capsules{0}e-enteric{0}e-coated, njengoba igama libonisa, amaphilisi angenalutho angancibiliki ngaphansi kokusebenza kwe-gastric acid kodwa angahlakazeka futhi akhulule izidakamizwa kuphela ngemva kokufinyelela endaweni ene-alkaline yamathumbu amancane. Ubuchwepheshe obuyinhloko butholakala ezintweni ezikhethekile kanye nezinqubo zegobolondo le-capsule. Ngokuvamile, izinto ezifana ne-gelatin ziphathwa zibe amafilimu anezici ze-enteric{3}}ezimbozwe ngokufakwa kwe-formaldehyde noma izindlela zokuncibilikisa. Lo mklamo usebenzisa ngobuhlakani izinguquko enanini le-pH lepheshana lesisu somuntu ukuze kuzuzwe ukukhululwa kwezidakamizwa okuhlosiwe.
2. Izinkambu Zokusebenza zama-Enteric{1}}Ama-Capsules Ahlanganisiwe
Ama-capsules{0}e-Enteric{0}ahlanganisiwe, anezinzuzo zawo eziyingqayizivele, enze izimpumelelo ezimangalisayo emikhakheni eminingi yezokwelapha, ikakhulukazi okuhlanganisa izici ezilandelayo:
Vikela Izithako Zomuthi Ezicekelwa Kalula Nge-Gastric Acid:
Izidakamizwa eziningi, ikakhulukazi amaprotheni, ama-peptide, izidakamizwa ze-hormone kanye nama-antibiotic athile, zijwayele kakhulu ukuwohloka nokungasebenzi kahle ngaphansi kwesenzo se-gastric acid. Amaphilisi e-Enteric-anamathelayo asebenza njenge-Protective Shell eqinile, emboza ngokuphephile le mithi, edlula Ezithiyo Eziningi Ze-gastric acid, futhi ekugcineni akhishwe ngokuphephile emathunjini amancane, okuqinisekisa ubuqotho nokusebenza kwezidakamizwa. Isibonelo, amalungiselelo omlomo ezidakamizwa ezifana ne-insulin, i-heparin namanye ama-antibiotic ngokuvamile asebenzisa ubuchwepheshe be-enteric{3}}coated capsule ukuze kuthuthukiswe i-bioavailability.
3. Thola futhi Ukhiphe Izidakamizwa Ukuze Uthuthukise Ukusebenza Kwazo:
Ama-capsules{0}e-enteric ahlanganiswe angakwazi ukuzuza ukukhululwa kwesidakamizwa okuhlosiwe futhi alethe imithi ngokunembile ezingxenyeni ezithile zamathumbu amancane. Lokhu kubaluleke kakhulu ekwelapheni izifo zamathumbu, njengesifo samathumbu esivuvukalayo kanye nomdlavuza wamathumbu. Ngokukhulula ngokuqondile umuthi endaweni yezilonda, ukuhlushwa kwezidakamizwa zendawo kungandiswa, umphumela wokwelapha ungathuthukiswa, futhi imiphumela emibi yesistimu ingancishiswa. Isibonelo, amaphilisi e-enteric-e-coated of 5-aminosalicylic acid (5-ASA) okwelapha i-ulcerative colitis angafinyelela ngqo esilonda futhi abe nomphumela omkhulu wokwelapha.
4. Lawula Izinga Lokukhishwa Kwezidakamizwa ukuze Uzuze Ukukhishwa Okumisiwe noma Okulawulwayo:
Ngokulungisa okubalulekile nokujiya kwegobolondo le-capsule eli-enteric-elinamekwe, izinga lokukhululwa lomuthi lingalawulwa ukuze kuzuzwe imiphumela-eqhubekayo noma elawulwayo{2}}yokukhishwa. Lokhu kuyasiza ekugcineni ukuzinza kwezidakamizwa zegazi, ukunciphisa imvamisa yokuphatha, kanye nokwenza ngcono ukuthobela kweziguli. Isibonelo, eminye imithi okudingeka iphuzwe isikhathi eside, njengezidakamizwa ezinciphisa umfutho wegazi ophakeme kanye nezidakamizwa ezilwa nesifo sokuqina kwemithambo yegazi, ingenziwa ibe amaphilisi-anamathela ngokuqinile{6}}e-enteric ukuze kuncishiswe imvamisa yokuphatha futhi anikeze imiphumela yokwelapha ezinzile.
5. Gwema Ukucasuka Kwezidakamizwa Esiswini:
Ezinye izidakamizwa zinomphumela onamandla ocasulayo ku-mucosa yesisu futhi zivame ukudala ukusabela okubi njengokucanuzela kwenhliziyo, ukuhlanza nobuhlungu besisu. Ama-capsules{1}e-enteric angavimbela ukuphuma kwezidakamizwa esiswini, ngaleyo ndlela ehlise ukucasuka kwesisu futhi athuthukise ukubekezelela kweziguli. Ngokwesibonelo, amanye amaphilisi okungewona-e-steroidal anti{4}}eqeda ukuvuvukala (ama-NSAID) angenziwa amakhepsuli{5}}ahlanganiswe nge-enteric ukuze kwehliswe umonakalo ku-gastric mucosa.
6. Ukuvala Iphunga Elingemnandi Nokunambitha Kwezidakamizwa:
Eminye imithi inephunga elibi kanye nokunambitha, okuthinta ulwazi lwemithi yeziguli. Ama-capsules{1}ahlanganisiwe e-Enteric angavala ngempumelelo iphunga lezidakamizwa futhi athuthukise ukuthobela izidakamizwa.
7. Isiphetho
Ama-capsules{0}enziwe nge-Enteric, njengobuchwepheshe obubalulekile bokulungiselela izidakamizwa, idlala indima engenakuthathelwa indawo ekuvikeleni izingxenye zezidakamizwa, ukuthola ukukhululwa, ukulawula izinga lokukhululwa, ukugwema ukucasuka kwesisu kanye nokuvala iphunga elibi. Ngokuthuthuka okuqhubekayo kobuchwepheshe bezokwelapha, izinkambu zokusetshenziswa kwama-enteric{1}}amakhepsuli angenalutho ahlanganiswe azoqhubeka nokunwetshwa, okuletha izindaba ezinhle ezigulini ezengeziwe. Ngokuzayo, sizobona ukuvela kwezinhlobo ezintsha ezengeziwe ze-enteric-zezinto ezimboziwe kanye nobuchwepheshe, ezikhuthaza ukuthuthukiswa kobuchwepheshe be-capsule{4}}ehlanganiswe nge-enteric ukuze busebenze kahle kakhulu, ukuphepha kanye nobuhlakani, nokwenza igalelo elikhulu embangela yempilo yabantu. Uma kukhona izimfuno kuma-capsules angenalutho, wamukelekile ukuthintanaKornnacCaps.
